MYC and erythroleukemia: While the member of the Myc network, Mxi and Mad1, turns the differentiation to erythroid direction, c‐Myc turns the direction to myelomonocytic differentiation.[100, 101] Zinc downregulates c‐Myc but upregulates Mad1, suggesting its importance in promoting erythroid differentiation, which benefits the therapy of erythroleukemia rather than myelomonocytic leukemia.[102] Overall, zinc appears to promote erythroid and lymphoid differentiation, but suppresses myelomonocytic differentiation, thus increasing the risk of myeloid leukemia.