ZNF384 rearrangement is common in ALL. High expression of ZNF384 is associated with poor survival in MLL and B‐ALL. Several ZNF384 fusions have been identified, including EP300‐ZNF384, CREBBP‐ZNF384, TCF3‐ZNF384, TCF4‐ZNF384, TAF15‐ZNF384, and EWSR1‐ZNF384. This evidence concerns the gene EP300 and acute lymphoblastic leukemia.