RARA and leukemia: Zinc supplementation was shown to promote the SUMO‐SIM interaction‐based recruitment of nuclear proteins to PML for the assembly of PML nuclear bodies (PML‐NBs), the unit for PML physiological functions.[73] While PML‐RARα disrupts the integrity of PML‐NBs, the re‐establishment of these nuclear bodies is critical for DNA damage repair in APL pathogenesis, suggesting a competitive relationship between PML‐NBs and PML‐RARα.[74, 75] Therefore, the low nuclear zinc in leukemia is predicted to inhibit the formation of PML‐NBs and thus maintain the stability of PML‐RARα.