Similar to KMT2A‐fusion driven disease, leukemia cell proliferation and self‐renewal as well as the underlying gene‐expression program could be abrogated by genetic inactivation of KMT2A or MEN1 as well as by the pharmacologic inhibition of the KMT2A–Menin interaction.75, 76, 78. Here, KMT2A is linked to leukemia.