The AUGMENT‐101 trial, initiated in 2019, assessed the oral Menin inhibitor Revumenib (SDNX‐5613; a close homologue to the preclinical VTP50469 compound) in patients with relapsed or refractory acute leukemia and was quickly amended to enroll only patients with KMT2A‐rearranged and NPM1‐mutated leukemia. Here, NPM1 is linked to leukemia.