As shown in Figure 6, the amount of apCAF (CD74+, PDGFα+) in pancreatic cancer was positively correlated with MSLN expression (P = 0.0026), but were negatively correlated with the amount of effector immune cells such as CD8+ T cells (p = 0.0165) and IFN‐γ+CD4+ T cells (p = 0.0014). This evidence concerns the gene CD4 and familial pancreatic carcinoma.