This phenomenon was further validated in another subcutaneous pancreatic tumor model, established by inoculating a mouse pancreatic cancer KPC cell line (Pdx1‐cre/LSL‐KrasG12D/P53R172H) overexpressing chicken ovalbumin (OVA) antigen and luciferase(KPC‐OVA‐Luc) (Figure S2A, Supporting Information), whose pathological characteristics closely resemble those of human pancreatic cancer. This evidence concerns the gene PDX1 and familial pancreatic carcinoma.