During the development of pancreatic cancer, mesothelial cells proliferate and acquire fibroblastic characteristics, further transforming into apCAFs.[9] Moreover, trauma‐ or inflammation‐related signals, such as IL‐1 and TGFβ signaling pathways, have been found to play crucial roles in driving the transformation of mesothelial cells into apCAFs.[22] Furthermore, apCAFs are capable of expressing MHC‐II molecules and presenting antigens to CD4+ T cells. Here, CD4 is linked to familial pancreatic carcinoma.