Single‐cell transcriptome analysis shows that the combined treatment significantly reduces the proportion of fibroblasts, improves the infiltration of IFN‐γ+CD4+ and GZMK+CD8+ T cells, as well as reduces the interaction of antigen presentation‐associated ligands and receptors between antigen‐presenting Cancer‐Associated Fibroblasts (apCAFs) and naive CD4+ T cells. The gene discussed is CD4; the disease is cancer.