Significantly, the expression of MSLN in tumor tissue from mice treated with αMSLN plus PanNV was significantly suppressed (similar to the result of MSLN antibody treatment alone) when comparing with the PanNV or PBS treated group (Combine vs PanNV: p = 0.0043, Combine vs PBS: p = 0.0003, Figure 3D,E), and the infiltration level of CD8+ T cells was also significantly higher than that in the other three groups (all p < 0.001, Figure 3F,G). Here, CD8A is linked to neoplasm.