The clinical phenotypes of the males carrying the MECP2 variants have ranged from severe neonatal encephalopathy to ID with parkinsonism and macro‐orchidism, with partly overlapping features (Table 1) (Chahil, Yelam, and Bollu 2008; Arvio et al. 2021). This evidence concerns the gene MECP2 and neonatal encephalopathy.