To gain a deeper understanding of how LEF1 depletion in exp‐CAF 544 cells led to the suppression of xenograft tumor, we conducted RNA‐seq analysis to compare the gene expression profiles of 544‐shCtrl and 544‐shLEF1s (shLEF1‐1, ‐3, and ‐9). This evidence concerns the gene LEF1 and neoplasm.