In our study cohort, long‐term survivors exhibited significantly higher proportions of total PBMCs at baseline compared to short‐term survivors, which aligns with studies on PD‐1/PD‐L1 checkpoint blockade in lung cancer and melanoma demonstrating significant association between lower baseline neutrophil‐to‐lymphocyte ratios and improved progression‐free and overall survival [31, 32]. This evidence concerns the gene CD274 and lung cancer.