IL1RN and Sepsis: Since IL1RN is the natural antagonist of IL1B and can competitively bind to the IL‐1 receptor to inhibit the IL‐1 pathway, high expression of IL1RN may play a critical role in suppressing the immune‐promoting effects of the IL‐1 pathway, thereby contributing to the immunosuppressive state observed in sepsis, suggesting the importance of the CD274+IL1RN+ neutrophil subpopulation in regulating the IL‐1 pathway.