Altogether, in immunosuppressive sepsis patients, the CXCR2+ neutrophil subpopulation might be related to CXCR2‐mediated neutrophil migration and thereby contribute to the dramatic increase in neutrophils, while N02 cells expressing IL1RN and CD274 may act as a major immunosuppressive neutrophil subpopulation. Here, IL1RN is linked to Sepsis.