We identified five subpopulations in BALF neutrophils from immunosuppressive sepsis patients: N00 (CXCR2+), N01 (S100A8/12+), N02 (CD274+IL1RN+), N03 (ISG15+), and N04 (CD63+) (Figure 4A,D). This evidence concerns the gene ISG15 and Sepsis.