PD‐L1 can bind to PD‐1 and promote immunosuppression through inhibiting survival, proliferation and function of effector CD4+ T cells and promoting CD4+ T cells to differentiate into immunosuppressive phenotype.[35] Therefore, we speculated that the increased expression of PD‐L1 in neutrophils may affect the differentiation and proliferation of CD4+ T cells, leading to immunosuppression in sepsis. Here, CD4 is linked to Sepsis.