Neutrophils have become an emerging therapeutic target in sepsis due to their important functions.[32] Specific subtypes has been identified in peripheral blood by previous studies.[17, 28, 39, 40] Besides, several studies have identified an immunosuppressive PD‐L1+ neutrophil subpopulation in peripheral blood of sepsis patients.[41, 42] These studies found that systemic inflammation and cytokines, such as IFN‐γ, influence the PD‐L1+ neutrophil subpopulation in peripheral blood. The gene discussed is CD274; the disease is Sepsis.