CXCL1 and Sepsis: To investigate the function of CXCL1/8‐CXCR2 in immunosuppressive stage of sepsis, CLP‐induced sepsis mice were intraperitoneally injected with SB225002, a CXCR2 selective non‐peptide antagonist (Figure 8A).[36] Compared with the vehicle group, the proportion and number of neutrophils and macrophages and CXCR2 expression in neutrophils in peripheral blood and BALF of the sepsis mice did not change (Figure 8B,C; Figure S8A–C, Supporting Information).