Although the RNA content of neutrophils was relatively low due to cell type properties, we still detected a substantial number of DEGs in sepsis patients, including decreased expression of genes related to the MHC‐II pathway (HLA‐DR) and increased expression of genes involved in immunosuppression, such as ARG1, CD274 and IL1RN (Figure 3A,E). This evidence concerns the gene CD274 and Sepsis.