CD274 and Sepsis: Immune‐promotive N1 neutrophils are characterized by their pro‐inflammatory properties, while immunosuppressive N2 neutrophils are characterized by their immunosuppressive properties and express surface markers such as programmed death ligand 1 (PD‐L1), ARG1, and MMP9.[24, 25, 26] Particularly, the expression of genes specifically regulating the immunosuppressive function of neutrophils, including CD274, ARG1, MMP9, and CCL2, were dramatically enhanced in neutrophils from sepsis patients compared to those from healthy controls (Figure 3A–C).