CD274+IL1RN+ mature neutrophils are an immunosuppressive neutrophil subset that participates in immunosuppression in the lung environment of patients with sepsis and is a unique cell population in the lung environment, different from the immunosuppressive IL1R2+ neutrophil subset in plasma.[17] Indeed, trajectory analysis revealed the developmental trajectory from CXCR2+ neutrophils to CD274+IL1RN+ neutrophils in sepsis BALF, consistent with the maturation state. The gene discussed is CXCR2; the disease is Sepsis.