S100A8 and Sepsis: Immature neutrophils mainly exist and mature in the bone marrow and then migrate to various organs along with the blood, with signature genes during the maturation stage.[27] By comparing the neutrophil maturation signature genes and neutrophil subgroups in sepsis blood,[17, 27] we found that S100A8+ neutrophils are likely to be more immature and originate from progenitors in the plasma, and under sepsis conditions, they migrate to the lungs.