The consistent observations in CLP mice and sepsis patients during the immunosuppressive phase indicated that not only the proportions of CXCR2+ and PD‐L1+ neutrophil subpopulations increased in sepsis, but also the expression of CXCR2 and PD‐L1, suggesting that these two subpopulations may play an essential role in the mechanism of sepsis‐induced immunosuppression. This evidence concerns the gene CD274 and Sepsis.