Examples of genomic rearrangements of enhancers can be found in adenoid cystic carcinoma (ACC), where a super‐enhancer translocates close to the MYB locus, establishing a positive feedback loop that sustains MYB overexpression100 and acute myeloid leukemia (AML), where an inversion repositions the GATA2 enhancer near the oncogene EVI1.101. The gene discussed is GATA2; the disease is acute myeloid leukemia.