IBC affects a wide spectrum of biological functions (Kuete and Sandjo, 2012), including the activity of the NAD+-dependent deacetylase Sirtuin 2 (Ren et al., 2024) and shows antitumor activity against drug-resistant cancers (Kuete et al., 2015; Ren et al., 2024; Wu et al., 2022). This evidence concerns the gene SIRT2 and cancer.