AFP and hepatocellular carcinoma: As liver damage is known to activate compensatory proliferation, which is thought to promote hepatocarcinogenesis (Inokuchi et al., 2010; Yang et al., 2013), we also evaluated the expression of Afp, a marker gene of hepatocellular carcinoma, and Mki67, a proliferation-related antigen, and found a significant increase in both markers in Ripk1-hepKO mice after fasting (Figure 2D).