RIPK1 and alcoholic liver diseases: RIPK1 deficiency in hepatocytes did not greatly affect the gene expression profiles when food was available and there were 25 up-regulated and 54 down-regulated genes which were mostly associated with alcoholic liver disease, vascular smooth muscle contraction and cardiomyopathy in Ripk1-hepKO mice compared to wild-type control at fed state (Figure 3—figure supplement 1D, E).