To summarize, our findings reinforce the previously established significance of platelet-VWF-ADAMTS13 axis in COVID-19.29 We have previously shown that different plasma products carry distinct coagulation profiles.40 Our novel discovery here suggested that LCP, a modified plasma product, increases VWF:Ag levels and enhances thrombin generation, despite adequate thromboprophylaxis. This evidence concerns the gene VWF and COVID-19.