Ceramides are key components of cellmembranes and play a crucial role in cellular signaling and apoptosis.Dysregulation of ceramide metabolism has been linked to various cancers.Moreover, given the importance of sphingolipids in the nervous system,dysfunction of COL4A3BP is known to be implicated in neurologicaldiseases.29 When comparing the COL4A3BPKO to control (Figure 1B), a few significant lipid species can be detected. This evidence concerns the gene CERT1 and cancer.