Tumor grade (P=0.033), immediate postoperative adjuvant therapy (P=0.031), Ki67 (P=0.030), P53 (P=0.048) and CK20 (P=0.044) were shown to be significantly independent risk indicators for postoperative recurrence of NMIBC by multivariate analysis Table 2. This evidence concerns the gene TP53 and neoplasm.