(62) observed that up-regulation of miRNA-155 and miRNA-21 in exosomes corresponded with a significant down-regulation of gene of phosphate and tension homology deleted on chromosome ten (PTEN) and B-cell CLL/lymphoma 6 (Bcl-6) expression in OSCC, indicating heightened proliferative activity and invasion potential in the cancer. This evidence concerns the gene PTEN and cancer.