In the central nervous system, Peng et al. demonstrated that BigH3 is elevated in the serum and cerebrospinal fluid (CSF) of glioblastoma patients and that TGFBI-expressing macrophages promoted the survival of glioma stem cells by avB5-Src-Stat3 signaling.78 In the heart, Schwanekamp et al. demonstrated thatBigH3 was enhanced in response to myocardial infarction. The gene discussed is TGFBI; the disease is myocardial infarction.