Our study revealed that patients with ALB≤30 g/L had shorter OS than those with ALB in the range 30–35 g/L, but the first-line chemotherapy response and PFS were not statistically different between the two groups, which demonstrated that hypoalbuminemia, especially when the ALB level dropped below 30 g/L, might severely affect the long-term survival of patients with EOC. Here, ALB is linked to Hypoalbuminemia.