Shared genetic factors have also been associated with elevated risk of CVD and cancer, including mutations of the JAK2, TTN, TET2 and ATM genes with gene network analyses highlighting links with DNA damage response pathways including homologous recombination.21 Mutations in genes including TET2 are also implicated in clonal haematopoiesis of indeterminate potential (CHIP). Here, TET2 is linked to cancer.