Although 2B4 signaling may be expressed in a variety of biological outputs through complex machineries and various situations; for example, expression levels of 2B4, its ligands, and other signaling molecules; type of cells; the surrounding tumor or inflammatory environments; T cell conditions; and other factors,6,7,17,18,19,56 it is clear that 2B4 plays an important role in regulating T cell functions and immunity. Here, CD244 is linked to neoplasm.