-CD11b, in combination with CD18, forms a αMβ2 heterodimer (Mac-1) (99). -Plays a crucial role in cell adhesion, phagocytosis, migration, and inflammation. Involved in innate immune responses. Important in inflammation, tissue injury, and autoimmunity. -Upregulated during infections and inflammatory conditions. Upregulated in eosinophil activation during inflammatory responses (93). The gene discussed is ITGB2; the disease is infection.