APOE and major depressive disorder: Moreover, for the Hamilton Depression Rating Scale emerged that females obtained an average score above the cut-off value besides APOE genotype (female APOE ε4 non-carriers = 7.56 ± 4.08; female APOE ε4 carriers = 7.66 ± 9.81; cut-off ≥ 6) (Lee et al., 2024).