CRP and major depressive disorder: However, it is noteworthy that within the 3-year follow-up period, therapeutic maintenance was significantly associated with several factors, including a Satisfied PGA, improved mobility and daily activities without discomfort, enhanced autonomy, the absence of pain and depression, the absence of new comorbidities, the absence of infections, BASDAI score <4, CRP levels below 6mg/L, and non-use of NSAIDs between visits.