Since most patients with LORA have an acute onset with intense inflammation, they tend to have highly raised inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and a higher degree of anaemia in comparison to patients with YORA.24 Even though earlier studies had shown a decreased prevalence of rheumatoid factor (RF) in patients with LORA, newer studies have not found significant differences in terms of RF and anti-citrullinated protein antibody (ACPA) positivity.25,26. The gene discussed is CRP; the disease is anemia (phenotype).