FOXF2 and neoplasm: Another recent study also showed higher expression of stromal FOXF2 in non-malignant TZ compared with PZ tissue, facilitating an anti-tumour immunity microenvironment that potentially contributed to the different outcomes between zones.36 It is crucial to consider additional future research to investigate the differences in tumour location and account for potential confounding factors to understand better the impact of the tumour’s origin on prognosis and treatment outcomes.