In multivariable models adjusted for sex and age (figure 3A), tumours from adjuvant chemotherapy-treated patients with a higher % of cluster 2 cells (higher XIAP, SMAC, cIAP1 and lower procaspase-3) had significantly increased recurrence risk (p=0.003), whereas tumours with higher % of cluster 4 cells (higher procaspase-9, low BAX and BAK) had significantly lower recurrence risk (p=0.003) (overall model was p<0.0001; AIC=172.91 and concordance index 0.77). This evidence concerns the gene BIRC2 and neoplasm.