We further investigated apoptosis sensitivity of these clusters using models of MOMP (DR_MOMP) and caspase-3 cleavage (APOPTO-CELL), which have been extensively validated in earlier works.10 17 24 37 38 We also recently applied both models to build a tumour atlas of apoptosis competency and showed marked inter-tumour and intra-tumour heterogeneity in MOMP sensitivity and caspase activation by cell type.26 The gene discussed is CASP3; the disease is neoplasm.