Furthermore, many genes related to synthesizing structural proteins involved in myelination include (PMP22, MPZ), proteins of axonal transport (NEFL), genes involved in Schwann cell differentiation (EGR2), gene controlling members of signal transduction pathways (NDGR1) and genes regulating mitochondrial function (MFN2) have been identified to be responsible for the appearance and progression of CMT [14,15]. This evidence concerns the gene NEFL and Charcot-Marie-Tooth disease.