EGFR-TKI-resistant non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an accumulation of LD and overexpression of Stearoyl-CoA Desaturase 1 (SCD-1), a key enzyme converting saturated fatty acids into unsaturated fatty acids [64]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.