SLC1A5 and peripheral neuropathy: Moreover, citrate can modulate ASCT2-mediated uptake of glutamine; previous research indicated that bortezomib (BTZ)-induced peripheral neuropathy led to decreased histone acetylation which may silence SLC1A5 expression (149), while another study suggested upregulation of ASCT2 in mice subjected to chronic social defeat stress due to excessive histone acetylation (150).