In summary, our meta-analysis indicates that significant causal relationships with osteoporosis’s onset and progression have been established for rheumatoid arthritis, inflammatory bowel disease, primary biliary cholangitis, non-alcoholic fatty liver disease, depression, sex hormone binding globulin, basal metabolic rate, gut microbiota (NB1n), and asthma. Here, SHBG is linked to rheumatoid arthritis.