Since involvement of GPR55 in cancerogenesis was mostly researched in the context of its role in cancer cells (18, 19, 26), we focused on the immune TME in this study using GPR55 KO mice, and explored whether the knockout of GPR55 could have an influence on the immune cell landscape and the tumor progression in a PDAC mouse model (27). This evidence concerns the gene GPR55 and neoplasm.