In Figure 4C (and Supplementary Figure S4), pathway enrichment analysis of RNA-seq data showed that the DEGs particularly correspond, among others, to pathways related to immune cell functions, such as antigen processing/presentation, signaling and differentiation of T cells, NK cell cytotoxicity, and checkpoint protein expression, indicating strong anti-tumor immune responses in KPCY55-induced tumors of GPR55 KO vs. WT mice. This evidence concerns the gene GPR55 and neoplasm.