Ulinastatin (Wu et al., 2019b), pterostilbene (Xue and Li, 2020), Taxifolin (Shen et al., 2022) and Maresin1 (Wang et al., 2020) all showed the effect of inhibiting JAK2/STAT3 signaling pathway to reduce inflammation in sepsis and protect lung injury. The gene discussed is STAT3; the disease is Sepsis.