GPT and metabolic disease: The two liver enzymes, alanine transaminase and aspartate aminotransferase, are used as clinical predictor of liver damage and cancer as they accumulate in diseased conditions [70], making the level of clearance from the circulatory system a diagnostic parameter of anticancer activity [71] Creatinine is a clinical marker of metabolic perturbations useful for detecting metabolic disorders and cancer [72], and hence, anticancer activity [73].