APC and colorectal carcinoma: The authors propose that the worst prognosis observed in CRC patients harboring APC C-terminal mutations is associated with the co-occurrence of alterations in genes involved in mitogenic pathways such as the Mitogen-Activated Protein Kinase (MAPK) and the Phosphoinositide 3-Kinase (PI3K) signaling pathways (Fig. 1E) [28].