Knockdown of circUCK2(2,3) resulted in downregulation of CNIH4 and SMAGP in HCC cells (Fig. 5D, and S9F), and overexpression of circUCK2(2,3) caused upregulation of CNIH4 and SMAGP in SNU398 (Fig. 5E) and SK-HEP-1 cells (Fig. S9G). The gene discussed is SMAGP; the disease is hepatocellular carcinoma.