Knockdown of circUCK2(2,3) resulted in downregulation of CNIH4 and SMAGP in HCC cells (Fig. 5D, and S9F), and overexpression of circUCK2(2,3) caused upregulation of CNIH4 and SMAGP in SNU398 (Fig. 5E) and SK-HEP-1 cells (Fig. S9G). This evidence concerns the gene CNIH4 and hepatocellular carcinoma.