In NPC and the other known EBV-associated cancers, EBV inhibits the FA-BRCA pathway by various methods, including using viral microRNAs to downregulate BRCA1 [14], hijacking other pathway components [15, 16], and destabilizing SMC5/6-mediated chromatin interactions [17, 18]. This evidence concerns the gene BRCA1 and nasopharyngeal carcinoma.