Specifically, the alcohol dehydrogenase class-3, 3-hydroxyacyl-CoA dehydrogenase type-2, the mitochondrial acyl-CoA dehydrogenase family, and the mitochondrial very long-chain specific acyl-CoA dehydrogenase, all of which were upregulated upon ZIKV infection. Here, ADH5 is linked to Zika virus infectious disease.