Of these seven circulating proteins, an increase in abundance of four proteins (dermatopontin (DPT), beta-crystallin B1 (CRYBB1), interleukin-18-binding protein (IL18BP) and vascular endothelial growth factor receptor 2 (KDR)) was associated with an increase in MM risk, while an increase in the abundance of 3 proteins (odorant-binding protein 2b (OBP2B), glutamate-cysteine ligase regulatory subunit (GCLM) and gamma-crystallin D (CRYGD)) was associated with decreased MM risk. The gene discussed is OBP2B; the disease is Miyoshi myopathy.