In contrast, KMT9α depletion in combination with either of the two ACLY inhibitors led to robust inhibition of PCa cell proliferation (Fig. 3m and Supplementary Fig. 10a–c), which was not observed in non-PCa cells (Fig. 3n and Supplementary Fig. 10d–g) devoid of mitochondrial KMT9. This evidence concerns the gene ACLY and posterior cortical atrophy.