In non-prostate cancer cells, expression of either KMT9α or NLS-KMT9α fully rescued the proliferation defect induced by KMT9α depletion, whereas MTS-KMT9α failed to do so, providing further evidence that mitochondrial KMT9 is not required (Supplementary Fig. 8a–j). The gene discussed is HEMK2; the disease is prostate carcinoma.