TGFB1 and cancer: Thus, depending on their location on the core-periphery axis, cancer cells from 3D spheroids express a diversity of transcriptional programs associated with embryonic states (pre-implantation at the periphery, post-gastrulation in the core), metastasis (EMT in the core), immunomodulation (complement, TGFb, interferon at the core), and survival (lipid metabolism, autophagy at the core).