Interestingly, in the monocytic acute leukemia line, THP-1, the single knock-out of caspase-7 led to increased intracellular bacteria growth of both Lm and Salmonella. Caspase-7, though structurally closely related to caspase-3, has a dual role in cell death and inflammation. The gene discussed is CASP3; the disease is acute leukemia.