KMT2D and lymphoma: In addition, this screen uncovered targets with predicted but less-well characterised links to lymphomas: Naa10 has been reported as necessary for TRP53-mediated apoptosis and was a hit in a similar Cas9-based screen performed by our group2,40, while Kmt2d has been reported to have tumour suppressive roles in acute myeloid leukaemia41 and lung squamous cell carcinoma42.