PMAIP1 and lymphoma: To this end, we tested constitutively expressed versions of individual pre-crRNAs and a 4-tandem-guide construct (targeting Trp53, Bim, Puma, and Noxa in parallel) in vitro, using primary enAsCas12aKI/KI MDFs and Eμ-MycT/+;enAsCas12aKI/+ lymphoma cells.