Across two independent experiments, all mice transplanted with crTrp53-transduced FLCs developed lymphoma by 28 days post-transplantation (consistent with the latency observed for mice reconstituted with Eμ-MycT/+ FLCs where Trp53 is knocked out using CRISPR-Cas916,20) (Fig. 1E). Here, TP53 is linked to lymphoma.