We note some predictable drop-outs occur even in the DMSO samples, including pre-crRNAs targeting eukaryotic translation elongation factor 2 (Eef2), an essential gene in protein synthesis24, and Mcl-1, the pro-survival BCL-2 family member upon which Eμ-Myc lymphoma cells are known to be most reliant25. This evidence concerns the gene MCL1 and lymphoma.