MYC and lymphoma: To expand our assessment of enAsCas12a activity to other cell types and biological contexts, homozygous enAsCas12aKI/KI female mice were crossed with Eμ-MycT/+ males (a well-characterised model for B cell lymphoma12,13), followed by generation of Eμ-MycT/+;enAsCas12aKI/+ lymphoma cell lines from the progeny that developed MYC-driven lymphoma.