In addition, this screen uncovered targets with predicted but less-well characterised links to lymphomas: Naa10 has been reported as necessary for TRP53-mediated apoptosis and was a hit in a similar Cas9-based screen performed by our group2,40, while Kmt2d has been reported to have tumour suppressive roles in acute myeloid leukaemia41 and lung squamous cell carcinoma42. Here, KMT2D is linked to neoplasm.