Subsequently, to understand how SND1 regulates the response of NSCLC cells to the chemotherapeutic agents, SND1 silencing was performed via the transfection with two different SND1-specific siRNAs in A549 cells (Fig. 1A, B) and H23 cells (Fig. 1C, D). The gene discussed is SND1; the disease is non-small cell lung carcinoma.