Gene set enrichment analysis (GSEA) further showed hallmarks of anti-tumor immune responses being upregulated in the mDKN01-treated tumors compared to IgG, including interferon-gamma response, interferon-alpha response, TNFα signaling via NFκB, and IL-2/STAT5 signaling (Fig. 4D). The gene discussed is NFKB1; the disease is neoplasm.