Notably, induced Bcl-6 knockdown in CD4+ T cells at days 36-41 post-tumor implantation, a later time point, had a negative impact on the survival of M002-treated mice with a median survival from 69 days in Bcl6fl/fl mice reduced to 46 days in Bcl6fl/flCD4CreER mice, although this late depletion of Bcl-6 had no discernable impact on the survival of saline-treated cohorts (Fig. 4j). The gene discussed is BCL6; the disease is neoplasm.