CD4 and neoplasm: M002 treatment also increased multiple pathways and their related receptor/ligand pairs involved in these interactions, with MHCII/CD4 interactions consistently highly represented among all three interactions between total CD4+ T cells, particularly cluster 2 cells, and microglia, myeloid or tumor cells, but not significantly upregulated between cluster 2 cells and non-T CD45+ cells (e.g., DCs) (Fig. 5h, i and Supplementary Fig. 8g, h).