CD4 and neoplasm: Notably, the increase in M002-treated CD4+ T-cell-mediated killing was largely MHCII-dependent, as pre-incubation of tumor cells with an anti-MHCII substantially diminished the increases in their killing potential to the extent as those saline-treated CD4+ T cells, while MHCII blockade did not have a discernable impact on saline-treated CD4+ T cells (Fig. 3b).