GSDMD and Sepsis: Disulfiram, necrosulfonamide and dimethyl fumarate inhibit oligomerisation and insertion of N-GSDMD into the cell membrane and have been found to suppress the inflammatory response and improve survival in murine sepsis models.93 94 Extension of these findings into humans has been limited by concerns about the blockade of GSDMD’s potential antimicrobial benefits and the finding that GSDMD knockout worsens renal and pulmonary pathology in murine inflammatory disease models.94