The NLRC4 inflammasome drives both Pseudomonas aeruginosa and isolated LPS-induced lung injury in mice, with NLRC4 knockout and inhibition of IL-1β both associated with reduced inflammation and improved outcomes.14 50 NLRC4 has also been implicated in Legionella pneumonia, Burkholderia pseudomallei, and Klebsiella pneumonia lung injury.51 This evidence concerns the gene NLRC4 and Legionnaires' disease.