NLRC4 and Sepsis: The NLRC4 inflammasome is also implicated in the development of sepsis in humans in response to pathogens, including Salmonella and P. aeruginosa.14 30 Additionally, isolated upregulation of the NLRC4 inflammasome in neutrophils is sufficient to cause severe systemic inflammation, and Wang et al demonstrated that silencing of NLRC4 ameliorated lung injury and inflammation in murine CLP.65 66 In contrast, the AIM2 inflammasome is protective in the initial response to infection in mice, with their blockade associated with worsened outcomes.67