NLRC4 and Klebsiella pneumonia: The NLRC4 inflammasome drives both Pseudomonas aeruginosa and isolated LPS-induced lung injury in mice, with NLRC4 knockout and inhibition of IL-1β both associated with reduced inflammation and improved outcomes.14 50 NLRC4 has also been implicated in Legionella pneumonia, Burkholderia pseudomallei, and Klebsiella pneumonia lung injury.51