Proteins involved in interferon-associated pathways, including type I and II interferon pathways, were specifically highly expressed in BRCA, ESCC, GBM, HNSC, KIRC, and PAAD (Supplemental Fig. S2, H and I), suggesting that a more immune-active tumor microenvironment in these cancers and possibly a better response to immunotherapy (68, 69). The gene discussed is SGCG; the disease is glioblastoma.