To achieve this, we defined a group of prognostic risk genes using LASSO-Cox algorithms based on PCUGs, PCDGs, PCCUPs, and PCCDPs, among which XPOT, SLC16A3, HM13, ACADS, MSRA, FXYD1A, TG9A, PLOD3, ADGRG1, PHF3, MAOB, and DYSF were identified as risk genes in at least two different cancer types. The gene discussed is PHF3; the disease is cancer.