In addition, the Pluronic-F127 used in this transplantation model could facilitate the delivery of active substances to the surrounding tissues as seen in the previous study that employed Pluronic-F127 to deliver the glycogen synthase kinase 3 beta (GSK3β) inhibitor (6-bromoindirubin-3′-oxime) and mitigate inflammatory responses effectively in ischemic stroke animal model [65]. Here, GSK3B is linked to ischemic stroke.