Previous research was limited to the relationship between congenital cataracts and nuclear receptor activity, whereas, in this study, a connection between Srebf1 in nuclear receptor activity and ARC has been established,that is, That is, compared with young mice, Srebf1 in the promoter region of elderly mice (i.e., the ARC group) shows hypomethylation and high expression(S4 Table). This evidence concerns the gene SREBF1 and early-onset non-syndromic cataract.