The present study evaluated the IgG reactivity to a panel of six malarial antigens, including GLURP-R2, MSP1, MSP3, and PfEMP1 domains (CIDRa1.1, CIDRa1.4, CIDRa1.5), which are associated with both malaria exposure and protection [21, 22, 35, 36] during three 4-monthly interventions and up to one year after the last intervention to assess whether IPTsc with either DP or ASAQ interferes with the natural immune responses to these six antigens. This evidence concerns the gene ATAD1 and malaria.