HOXA9 and acute myeloid leukemia: To further examine the role of HOXBLINC in NUP98-HOXA9–driven aberrant gene expression patterns and leukemogenesis, we inhibited HOXBLINC RNA expression using a lentivirus with shRNA-mediated gene silencing (Supplemental Figure 8B) and conducted RNA-Seq analysis of WT and HOXBLINC-KD in primary AML cells from patients 1265 and 1292 harboring the NUP98-HOXA9 fusion.