PHF23 and precursor B-cell acute lymphoblastic leukemia: Colocalization analysis of images of V5-tagged NUP98-PHF23 fusion proteins and H3K4me3 staining indicated that HoxBlinc KO markedly reduced colocalization of NUP98-PHF23 and H3K4me3 within the NUP98-PHF23 fusion–driven B-ALL nucleus (Supplemental Figure 4I), supporting the idea that HoxBlinc lncRNA plays an important role in regulating NUP98-PHF23–directed leukemic genome organization, the chromatin landscape, and the transcription signature.