CTCF and precursor B-cell acute lymphoblastic leukemia: To further investigate the underlying mechanisms by which HoxBlinc lncRNA regulates NUP98-PHF23–mediated oncogenic homeotic gene transcription, we carried out ChIRP-Seq, ChIP-Seq, ATAC-Seq, and Hi-C analyses in WT versus HoxBlinc-KO 961C B-ALL cells to examine the alterations in global HoxBlinc and CTCF chromatin binding, as well as the corresponding changes in TAD formation and the chromatin landscape.