Given that the Hoxb-associated lncRNA HoxBlinc is activated in NPM1C+ AML cells to promote NPM1C+-driven leukemogenic Hoxa/b clusters and the Meis1 signature (22), we sought to test whether and how HoxBlinc lncRNA is a critical downstream mediator of the NUP98-PHF23 fusion oncoprotein to drive the homeotic leukemic transcription signature and leukemogenesis. This evidence concerns the gene PPIB and acute myeloid leukemia.