Given that HoxBlinc lncRNA acts as a potential regulator of Hox gene transcription in normal and malignant hemopoiesis (21, 22), we performed RNA-Seq to compare changes in NUP98-PHF23–driven transcriptome profiles in WT versus HoxBlinc-deficient 961C or A1929 B-ALL cells. Here, NUP98 is linked to acute lymphoblastic leukemia.