To further investigate the underlying mechanisms by which HoxBlinc lncRNA regulates NUP98-PHF23–mediated oncogenic homeotic gene transcription, we carried out ChIRP-Seq, ChIP-Seq, ATAC-Seq, and Hi-C analyses in WT versus HoxBlinc-KO 961C B-ALL cells to examine the alterations in global HoxBlinc and CTCF chromatin binding, as well as the corresponding changes in TAD formation and the chromatin landscape. The gene discussed is PHF23; the disease is precursor B-cell acute lymphoblastic leukemia.