CD8A and neoplasm: To further explore the impact of elevated lactate accumulation on infiltrated TAMs and CD8+ T cells at the single-cell level, we analyzed public single-cell RNA sequencing (scRNA-Seq) datasets of PDAC (Gene Expression Omnibus [GEO] GSE205013; National Genomics Data Center CRA001160; Human Tumor Atlas Network PHS002371; GEO GSE212966) (Supplemental Figure 1D) (31–34).